People
John Clemmer, PhD
 | Assistant Professor Office/Lab: G152; (601) 984-1802 |
Areas of expertise
- General: Cardiovascular and renal physiology
- Specific: Physiological modeling of hypertension, kidney disease, and heart failure
Research methods
- Mathematical models of hypertension and cardiovascular renal diseases
- Validating virtual populations to replicate clinical trials
- Advanced data analytics and machine learning on clinical datasets
- Developing algorithms to clean and organize Research Data Warehouse outputs
Current Projects
- Impact of renal dysfunction in Black Americans with heart failure with preserved ejection fraction
- Modeling the renoprotective mechanisms of SGLT2 inhibition in hypertensive chronic kidney disease
- Role of the heart and kidney in heart failure with preserved ejection fraction during baroreflex activation therapy
- Modeling mechanisms of salt-sensitivity
Dr. Clemmer's research uses mathematical modeling to understand integrative physiology and interactions with novel therapies. He currently develops and uses the large model, HumMod, to model and validate pharmacological and device-based therapy for the treatment of the treatment of hypertension, chronic kidney disease, and heart failure with preserved ejection fraction, which are frequently seen together, especially during obesity. Dr. Clemmer also uses the model to create virtual populations to simulate clinical trials and validate population responses to different treatment options.
Dr. Clemmer also uses UMMC's large Research Data Warehouse to uncover the impact of factors such as socioeconomics, race, and sex in the response to cardiac and renal therapies. The Research Data Warehouse is a large database with >50 million electronic health records form >1 million patients treated at UMMC hospitals.
Postdoctoral Positions
Dr. Clemmer's laboratory is interested in attracting candidates with a strong background in integrative physiology. Experience in computational modeling or predictive analytics is a plus. To apply, email a cover letter, CV and a list of two references to Dr. Clemmer.
For more information